Download Systematic Evaluation of the Mouse Eye PDF

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Publisher : CRC Press
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ISBN 10 : 084930864X
Pages : 384 pages
Rating : 4.3/5 (38 users)

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Download Systematic Evaluation of the Mouse Eye PDF by Richard S. Smith Full Free and published by CRC Press. This book was released on 2001-12-20 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the first phase of the Human Genome Project has presented scientists with a mountain of new information. The availability of all human genes and their locations is exciting, but their mechanisms of action and interaction with other genes are often unknown. Certain variations in the environment and characteristics of human genes make it difficult for scientists to maximize their efforts to take advantage of this new fund of knowledge. The high degree of similarity between mouse and human genomes and physiology has made mice the laboratory animals of choice in the search for models of human disease. In recent years significant advances in our ability to examine the mouse eye and to view vascular and neural structures in vivo has led to a marked increase in interest in mouse ocular pathology and development. Besides providing much new information, Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods provides investigators with a resource that summarizes the widely scattered information on mouse eye anatomy, development, and pathology. It describes the normal anatomy, pre- and postnatal development, regional pathology, and methodology for evaluation of the mouse eye and adnexae. The first section covers the principal features of mouse eye anatomy and development. The second part discusses issues in evaluation of mutations in mice, including background ocular disease, control selection, quantitative traits, and ENU mutagenesis. With this background in place, the book then reviews and illustrates regional ocular pathology and correlates it with human eye disease. Many of the contributors who have helped develop and refine the specialized techniques necessary for the examination and preparation of mouse eye tissue for microscopy provide "how-to" chapters. These chapters cover methods for necropsy, photography, histopathology, confocal microscopy, intraocular pressure measurement, and electroretinography. Systematic Evaluation of the Mouse Eye: Anatomy, Pathology, and Biomethods provides the first comprehensive and systematic guide to understanding the development, structure, and abnormal pathology of the mouse eye so you can make the most of your genetic research.


Download Systematic Evaluation of the Mouse Eye PDF

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Publisher : CRC Press
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ISBN 10 : 9781420041606
Pages : 383 pages
Rating : 4.4/5 (42 users)

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Download Systematic Evaluation of the Mouse Eye PDF by Richard S. Smith Full Free and published by CRC Press. This book was released on 2001-12-20 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completion of the first phase of the Human Genome Project has presented scientists with a mountain of new information. The availability of all human genes and their locations is exciting, but their mechanisms of action and interaction with other genes are often unknown. Certain variations in the environment and characteristics of human genes make i


Download The Mouse in Biomedical Research PDF

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Publisher : Elsevier
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ISBN 10 : 0080469078
Pages : 816 pages
Rating : 4.4/5 (469 users)

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Download The Mouse in Biomedical Research PDF by Full Free and published by Elsevier. This book was released on 2006-12-15 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Normative Biology, Husbandry, and Models, the third volume in the four volume set, The Mouse in Biomedical Research, encompasses 23 chapters whose contents provide a broad overview on the laboratory mouse’s normative biology, husbandry, and its use as a model in biomedical research. This consists of chapters on behavior, physiology, reproductive physiology, anatomy, endocrinology, hematology, and clinical chemistry. Other chapters cover management, as well as nutrition, gnotobiotics and disease surveillance. There are also individual chapters describing the mouse as a model for the study of aging, eye research, neurodegenerative diseases, convulsive disorders, diabetes, and cardiovascular and skin diseases. Chapters on imaging techniques and the use of the mouse in assays of biological products are also included.


Download A Practical Guide to the Histology of the Mouse PDF

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Publisher : John Wiley & Sons
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ISBN 10 : 9781119941200
Pages : 258 pages
Rating : 4.1/5 (119 users)

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Download A Practical Guide to the Histology of the Mouse PDF by Cheryl L. Scudamore Full Free and published by John Wiley & Sons. This book was released on 2014-02-10 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. Written by experienced pathologists and specifically tailored to the needs of scientists and histologists Full colour throughout Provides advice on sampling tissues, necropsy and recording data Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation


Download Pathology of Genetically Engineered and Other Mutant Mice PDF

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Publisher : John Wiley & Sons
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ISBN 10 : 9781119624578
Pages : 564 pages
Rating : 4.1/5 (119 users)

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Download Pathology of Genetically Engineered and Other Mutant Mice PDF by John P. Sundberg Full Free and published by John Wiley & Sons. This book was released on 2022-01-26 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated and comprehensive reference to pathology in every organ system in genetically modified mice The newly revised and thoroughly updated Second Edition of Pathology of Genetically Engineered and Other Mutant Mice delivers a comprehensive resource for pathologists and biomedical scientists tasked with identifying and understanding pathologic changes in genetically modified mice. The book is organized by body system, includes descriptions and explanations of a wide range of findings, as well as hundreds of color photographs illustrating both common and rare lesions that may be found in genetically engineered and wild type mice. The book is written by experienced veterinary and medical pathologists working in veterinary medical colleges, medical colleges, and research institutes. Covering the latest discoveries in mouse pathology resulting from advancements in biotechnology research over the last 30 years, this singular and accessible resource is a must-read for veterinary and medical pathologists and researchers working with genetically engineered and other mice. Readers will also benefit from: A thorough introduction to mouse pathology and mouse genetic nomenclature, as well as databases useful for analysis of mutant mice An exploration of concepts related to validating animal models, including the Cinderella Effect Practical discussions of basic necropsy methods and grading lesions for computational analyses Concise diagnostic approaches to the respiratory tract, the oral cavity and GI tract, the cardiovascular system, the liver and pancreas, the skeletal system, and other tissues As a one-stop and up to date reference on mouse pathology, Pathology of Genetically Engineered and Other Mutant Mice is an essential book for veterinary and medical pathologists, as well as for scientists, researchers, and toxicologists whose work brings them into contact with genetically modified mice.


Download Morphological Mouse Phenotyping PDF

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Publisher : Elsevier
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ISBN 10 : 9780128128770
Pages : 602 pages
Rating : 4.1/5 (128 users)

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Download Morphological Mouse Phenotyping PDF by Jesus Ruberte Full Free and published by Elsevier. This book was released on 2017 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man. Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organsIncludes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona)Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology.


Download Recent Advances In Retinal Degeneration PDF

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Publisher : Springer Science & Business Media
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ISBN 10 : 9780387749044
Pages : 424 pages
Rating : 4.3/5 (387 users)

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Download Recent Advances In Retinal Degeneration PDF by Robert E. Anderson Full Free and published by Springer Science & Business Media. This book was released on 2007-12-03 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The product of perhaps the most important research meeting in the field, this essential text outlines all the latest research in retinal degeneration. Culled from the proceedings of the International Symposium on the subject, the topics in this volume explore the etiology, cellular mechanisms, epidemiology, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration. A must-read for researchers in the field.


Download Assessing Ocular Toxicology in Laboratory Animals PDF

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Publisher : Springer Science & Business Media
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ISBN 10 : 9781627031646
Pages : 322 pages
Rating : 4.6/5 (627 users)

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Download Assessing Ocular Toxicology in Laboratory Animals PDF by Andrea B Weir Full Free and published by Springer Science & Business Media. This book was released on 2012-12-04 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ocular toxicity is routinely assessed in toxicology studies conducted for regulatory purposes. Ocular anatomy and physiology and the assessment of ocular toxicity itself can be challenging to scientists involved in the safety assessment of pharmaceuticals, pesticides and other agents. Anatomical and physiological differences between species can impact the nature of ocular effects observed following intended or unintended exposure of ocular tissues to xenobiotics. Ocular Toxicity in Laboratory Animals provides a concise reference addressing ocular anatomy and physiology across species that will enhance the design and interpretation of toxicology studies conducted for regulatory purposes. The book provides an overview of routine and advanced techniques that are used to assess ocular toxicity including slit lamp biomicroscopy, indirect ophthalmoscopy, electrophysiology and imaging methods for the anterior and posterior segments of the eye. Additionally, the book defines the regulatory expectations for pharmaceuticals intended to treat ocular diseases and for other non-pharmaceutical regulated chemicals. With contributions from experts in the field, Ocular Toxicity in Laboratory Animals is an authoritative, accessible guide for toxicologists and other scientists involved in conducting toxicology studies for regulatory purposes and/or reviewing data from such studies.


Download The Laboratory Mouse PDF

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Publisher : Academic Press
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ISBN 10 : 9780123820082
Pages : 869 pages
Rating : 4.1/5 (123 users)

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Download The Laboratory Mouse PDF by Hans Hedrich Full Free and published by Academic Press. This book was released on 2012-07-16 with total page 869 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mice have long been recognized as a valuable tool for investigating the genetic and physiological bases of human diseases such as diabetes, infectious disease, cancer, heart disease, and a wide array of neurological disorders. With the advent of transgenic and other genetic engineering technologies, the versatility and usefulness of the mouse as a model in biomedical research has soared. As a result, mouse colonies everywhere are expanding, and scientists who previously focused on other models are turning their attention to the mouse. Revised to reflect advances since the first edition, The Laboratory Mouse, Second Edition continues to be the most accessible reference on the biology and care of the laboratory mouse. This guide presents basic information and common procedures in detail to provide a quick reference source for investigators, technicians, and caretakers in the humane care and use of the mouse in the laboratory setting. Expanded, updated, and now in color, this new edition includes coverage of the biological features, husbandry, management, veterinary care, experimental methodology, and resources applying specifically to the mouse"--Provided by publisher.


Download Mouse Development PDF

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Publisher : Springer Science & Business Media
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ISBN 10 : 9783642304064
Pages : 440 pages
Rating : 4.6/5 (642 users)

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Download Mouse Development PDF by Jacek Z. Kubiak Full Free and published by Springer Science & Business Media. This book was released on 2012-08-23 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mouse is a perfect model organism to study mammalian, and thus indirectly also human, embryology. Most scientific achievements that have had an important impact on the understanding of basic mechanisms governing embryo development in humans, originated from mouse embryology. Stem cell research, which now offers the promise of regenerative medicine, began with the isolation and culture of mouse embryonic stem cells by Martin Evans (who received the Nobel Prize in medicine in 2007 for this achievement) and Matthew Kaufman. This book provides an overview of mouse development, spanning from oocytes before fertilization to the state-of-the-art description of embryonic and adult stem cells. The chapters, written by the leading specialists in the field, deal with the most recent discoveries in this extremely fast-developing area of research.


Download Histologic Basis of Mouse Endocrine System Development PDF

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Publisher : CRC Press
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ISBN 10 : 9781420088199
Pages : 252 pages
Rating : 4.4/5 (42 users)

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Download Histologic Basis of Mouse Endocrine System Development PDF by Matthew Kaufman Full Free and published by CRC Press. This book was released on 2016-04-19 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transform Your Computer Monitor into a Virtual MicroscopeThe world's leading expert on mouse embryology, Dr. Matthew Kaufman is responsible for producing classic texts that are considered the most respected in the field. While the quality of their photowork at the time was considered state-of-the-art, the technology available when the books were pr


Download Genetically Engineered Mice Handbook PDF

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Publisher : CRC Press
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ISBN 10 : 9781420039078
Pages : 336 pages
Rating : 4.4/5 (42 users)

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Download Genetically Engineered Mice Handbook PDF by John P. Sundberg Full Free and published by CRC Press. This book was released on 2016-04-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: While mice have always been highly popular laboratory subjects, their suitability for genetic engineering has solidified their position as today's lab animal model of choice. However, their increased use in genetic studies has created a demand for input on phenotyping that is not always easily met. To improve the flow of information on the pathology of mice with spontaneous or genetically engineered mutations, prominent researchers organized a series of meetings. Recognizing other needs, the organizers gradually broadened their focus, until finally they expanded to provide an overview of the entire field of genetically engineered models. The Genetically Engineered Mice Handbook is an extension of those meetings. It offers an introduction for those entering into this area of research, while also serving as a resource for those presently employing mice as laboratory models. Highly comprehensive, this volume covers pertinent aspects of genetically engineered mice, including the use of models for developmental biology and the monitoring of laboratory colonies. With contributions from nearly five-dozen leading researchers, the text presents systematic approaches for analyzing mutant mice for specific medical applications, details a variety of methods for creating mutants and includes information that is particularly hard to access dealing with legal responsibilities. This essential reference examines commonly used traditional, as well as emerging, technologies To address the purpose of the original meeting, the Genetically Engineered Mice Handbook directs researchers to the best public websites, and offers instruction on how to use them. In the past, as their work dictated, researchers would seek out experts on particular organ systems. Now groups of experts work together to generate these websites, providing the latest data as well as discussions over points of debate. These sites do not eliminate the need for a trained pathologist, but they do provide reference materials for those lacking expertise in particular anatomic structures. They also offer much greater numbers of examples than are available in print, from which biomedical researchers can draw.


Download Myopia PDF

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Publisher : World Scientific
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ISBN 10 : 9789812832986
Pages : 420 pages
Rating : 4.8/5 (812 users)

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Download Myopia PDF by Roger W. Beuerman Full Free and published by World Scientific. This book was released on 2010 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Section 1. Epidemiology and risk factors. ch. 1.1. Epidemiology of myopia and myopic shift in refraction / Barbara E.K. Klein. ch. 1.2. Environmental risk factors for myopia in children / Wilson C.J. Low, Tien-Yin Wong and Seang-Mei Saw. ch. 1.3. Gene-environment interactions in the aetiology of myopia / Ian G. Morgan and Kathryn A. Rose. ch. 1.4. The economics of myopia / Marcus C.C. Lim and Kevin D. Frick -- Section 2. Clinical studies and pathologic myopia. ch. 2.1. Quality of life and myopia / Ecosse L. Lamoureux and Hwee-Bee Wong. ch. 2.2. Ocular morbidity of pathological myopia / V. Swetha E. Jeganathan, Seang-Mei Saw and Tien-Yin Wong. ch. 2.3. Myopia and glaucoma / Shamira A. Perera and Tin Aung. ch. 2.4. The myopic retina / Shu-Yen Lee. ch. 2.5. Retinal function / Chi D. Luu and Audrey W.L. Chia -- Section 3. Genetics of myopia. ch. 3.1. New approaches in the genetics of myopia / Liang K. Goh, Ravikanth Metlapally and Terri Young. ch. 3.2. Twins studies and myopia / Maria Schäche and Paul N. Baird. ch. 3.3. TIGR, TGFB1, cMET, HGF, collagen genes, and myopia / Chiea-Chuen Khor. ch. 3.4. Statistical analysis of genome-wide association studies for myopia / Yi-Ju Li and Qiao Fan -- Section 4. Animal models and the biological basis of myopia. ch. 4.1. The relevance of studies in chicks for understanding myopia in humans / Josh Wallman and Debora L. Nickla. ch. 4.2. The mechanisms regulating scleral change in myopia / Neville A. McBrien. ch. 4.3. The mouse model of myopia / Frank Schaeffel. ch. 4.4. Gene analysis in experimental animal models of myopia / Roger W. Beuerman, Liang K. Goh and Veluchamy A. Barathi -- Section 5. Interventions for myopia. ch. 5.1. Atropine and other pharmacological approaches to prevent myopia / Louis M.G. Tong, Veluchamy A. Barathi and Roger W. Beuerman. ch. 5.2. Physical factors in myopia and potential therapies / Wallace S. Foulds and Chi D. Luu


Download Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection PDF

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Publisher : Newnes
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ISBN 10 : 9780444532565
Pages : 640 pages
Rating : 4.4/5 (444 users)

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Download Glaucoma: An Open-Window to Neurodegeneration and Neuroprotection PDF by Carlo Nucci Full Free and published by Newnes. This book was released on 2008-11-21 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glaucoma is one of the main causes of blindness throughout the world. It is characterized by death of the retinal ganglion cells, which is associated with loss of the axons making up the optic nerve. Recent studies have demonstrated support for the classification of glaucoma as a degenerative disease of the central nervous system (CNS). The search for treatment modalities that are effective for all patients with glaucoma has resulted in numerous studies aimed at identifying neuroprotection strategies for the treatment of this disease, like those used for other degenerative diseases of the CNS. The present book will provide an in-depth examination of the most recent findings regarding glaucoma, including risk factors, diagnosis, clinical monitoring, treatment, and above all, the need for treatment based on the concept of neuroprotection. A large part of the book is devoted to research related to this new approach to the treatment of glaucoma. Aspects that will be analyzed include experimental models of glaucoma, clinical protocols for the study of neuroprotective therapies, mechanisms underlying glaucomatous damage to neurons of the retina and other “stations? in the visual pathways of the CNS, and finally proposals for new strategies for preventing neuronal injury in glaucoma patients. * Describes the most recent developments on neuroprotection of the optic nerve, including experimental models now used and clinical protocols * Discusses new strategies for the prevention of neuronal injury in glaucoma patients * Focuses on evidence-based risk factors, innovative diagnostic aspects and advanced medical/surgical treatment of glaucoma


Download Mutagenesis of the Mouse Genome PDF

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Publisher : Springer Science & Business Media
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ISBN 10 : 9781402050572
Pages : 98 pages
Rating : 4.4/5 (42 users)

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Download Mutagenesis of the Mouse Genome PDF by Monica Justice Full Free and published by Springer Science & Business Media. This book was released on 2007-11-12 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.


Download Encyclopedia of the Eye PDF

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Publisher : Academic Press
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ISBN 10 : 9780123742032
Pages : 4832 pages
Rating : 4.1/5 (123 users)

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Download Encyclopedia of the Eye PDF by Joseph Besharse Full Free and published by Academic Press. This book was released on 2010-05-27 with total page 4832 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the first comprehensive reference for the eye, its support structures, diseases, and treatments, Encyclopedia of the Eye is an important resource for all visual scientists, ophthalmologists, and optometrists, as well as researchers in immunology, infectious disease, cell biology, neurobiology and related disciplines. This four-volume reference is unique in its coverage of information on all tissues important for vision, including the retina, cornea and lens. It also covers the physiological and pathophysiologic processes that affect all eye tissues. This Encyclopedia is invaluable for graduate students and postdoctoral fellows who are seeking an introduction to an area of eye research. Each chapter explains the basic concepts and provides references to relevant chapters within the Encyclopedia and more detailed articles across the wider research literature. The Encyclopedia is also particularly useful for visual scientists and practitioners who are researching a new area, seeking deeper understanding of important research articles in fields adjacent to their own, or reviewing a grant outside their immediate area of expertise. Written by experts at a level that permits students to grasp key elements of a specific subject Provides an entryway into the major features of current eye research No other source puts this much information, so well-indexed and with so many helpful full color figures and graphics, in the hands of the ophthalmic scientist


Download Standards of Mouse Model Phenotyping PDF

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Publisher : John Wiley & Sons
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ISBN 10 : 9783527608706
Pages : 358 pages
Rating : 4.5/5 (527 users)

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Download Standards of Mouse Model Phenotyping PDF by Martin Hrabé de Angelis Full Free and published by John Wiley & Sons. This book was released on 2009-09-03 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.