Download Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU PDF

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Publisher : Academic Press
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ISBN 10 : 9780128212523
Pages : 346 pages
Rating : 4.1/5 (128 users)

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Download Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU PDF by Gianni Dal Negro Full Free and published by Academic Press. This book was released on 2021-11-18 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU provides updated information on the EU Directive 2010/63/EU, which is the European Union legislation that protects animals being used in research. EU Directive 2010/63/EU is the European Union (EU) legislation 'on the protection of animals used for scientific purposes' and is one of the most stringent ethical and welfare standards worldwide. Closes a gap in scientific literature by addressing the need for clear guidance in walking through the multifaced universe of 3Rs Offers a useful starting point for readers and scientist who approach the 3Rs for the first-time Gives insights into the harmonization of the animal research legislation across countries


Download Handbook of Laboratory Animal Science PDF

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Publisher : CRC Press
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ISBN 10 : 9780429801594
Pages : 1012 pages
Rating : 4.4/5 (429 users)

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Download Handbook of Laboratory Animal Science PDF by Jann Hau Full Free and published by CRC Press. This book was released on 2021-05-17 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.


Download Animal-centric Care and Management PDF

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Publisher : CRC Press
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ISBN 10 : 9780429602054
Pages : 190 pages
Rating : 4.4/5 (429 users)

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Download Animal-centric Care and Management PDF by Dorte Bratbo Sørensen Full Free and published by CRC Press. This book was released on 2020-10-14 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management: Enhancing Refinement in Biomedical Research takes Russell and Burch’s definition of Refinement as "elimination of inhumanities" and goes further. Rather than fitting animals into experimental conditions, it encourages readers to adjust conditions to better meet the behavioral, emotional, physical, and physiological needs and preferences of the animals. The team of expert authors, from the fields of laboratory animal science, ethology, biology as well as animal training, provide ideas for creating housing conditions and handling procedures that induce, to the best of current abilities and knowledge, a long-term positive state of mind in the animals under our care. This book is written for animal caretakers, animal health technicians, researchers, animal facility managers, laboratory animal veterinarians, and anyone who engages in work with living experimental animals or is interested in the continuous improvement of laboratory animal welfare. This interdisciplinary guide will act as a catalyst, resulting in multiple viewpoints and fields collaborating to optimize laboratory animal welfare.


Download The Role of the Study Director in Nonclinical Studies PDF

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Publisher : John Wiley & Sons
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ISBN 10 : 9781118370391
Pages : 568 pages
Rating : 4.1/5 (118 users)

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Download The Role of the Study Director in Nonclinical Studies PDF by William J. Brock Full Free and published by John Wiley & Sons. This book was released on 2014-06-03 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry


Download Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms PDF

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Publisher : Academic Press
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ISBN 10 : 9780128224960
Pages : 780 pages
Rating : 4.1/5 (128 users)

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Download Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms PDF by Loutfy H. Madkour Full Free and published by Academic Press. This book was released on 2020-06-27 with total page 780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment


Download Wildlife Welfare PDF

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Publisher : Frontiers Media SA
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ISBN 10 : 9782889664269
Pages : 132 pages
Rating : 4.8/5 (889 users)

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Download Wildlife Welfare PDF by Charlotte Lotta Berg Full Free and published by Frontiers Media SA. This book was released on 2021-01-25 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: