Download Adult Stem Cell Therapies: Alternatives to Plasticity PDF

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Publisher : Humana Press
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ISBN 10 : 1493955039
Pages : 266 pages
Rating : 4.9/5 (955 users)

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Download Adult Stem Cell Therapies: Alternatives to Plasticity PDF by Mariusz Z. Ratajczak Full Free and published by Humana Press. This book was released on 2016-09-10 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume explores various techniques for tissue and organ regeneration using stem cells isolated from adult tissues. It discusses alternative explanations of stem cell plasticity as well as current clinical results with adult stem cell therapies. It examines the presence of potential pluripotent stem cells in adult tissues, paracrine effects of stem cell therapies, and involvement of exosomes and microparticles into observed phenomena. Fifteen chapters, all written by noted leaders of their fields, focus on a variety of topics including cord blood and hematopoietic stem cells, skin and tissue organ regeneration, very small embryonic-like stem cells, and cell therapies in cardiology, neonatology, and neurology. Edited by Dr. Mariusz Ratajczak, an internationally known specialist in adult stem cell biology, Adult Stem Cell Therapies: Alternatives to Plasticity is an important addition to the Stem Cell Biology and Regenerative Medicine series.


Download Adult Stem Cell Therapies: Alternatives to Plasticity PDF

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Publisher : Springer
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ISBN 10 : 9781493910014
Pages : 266 pages
Rating : 4.4/5 (493 users)

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Download Adult Stem Cell Therapies: Alternatives to Plasticity PDF by Mariusz Z. Ratajczak Full Free and published by Springer. This book was released on 2014-09-10 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume explores various techniques for tissue and organ regeneration using stem cells isolated from adult tissues. It discusses alternative explanations of stem cell plasticity as well as current clinical results with adult stem cell therapies. It examines the presence of potential pluripotent stem cells in adult tissues, paracrine effects of stem cell therapies, and involvement of exosomes and microparticles into observed phenomena. Fifteen chapters, all written by noted leaders of their fields, focus on a variety of topics including cord blood and hematopoietic stem cells, skin and tissue organ regeneration, very small embryonic-like stem cells, and cell therapies in cardiology, neonatology, and neurology. Edited by Dr. Mariusz Ratajczak, an internationally known specialist in adult stem cell biology, Adult Stem Cell Therapies: Alternatives to Plasticity is an important addition to the Stem Cell Biology and Regenerative Medicine series.


Download Adult Stem Cells PDF

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Publisher : Humana
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ISBN 10 : 1588291529
Pages : 346 pages
Rating : 4.2/5 (291 users)

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Download Adult Stem Cells PDF by Kursad Turksen Full Free and published by Humana. This book was released on 2004-01-27 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies on stem cells have been attracting intense scientific and p- lic attention, not only because of controversies surrounding the use of embryonic stem cells but also because of very provocative data that have been emerging on adult stem cells. Much of the public attention and debate has been focused on the possibility that adult stem cells may be used as a substitute for human embryonic stem cells or as a justification for stopping work on them. This has somewhat dim- ished attention on very heated scientific debates that take us to the very heart of how the concept of stem cells is perceived. To this author, the latter debates have not been unlike certain philosophical debates of the last century. Since the seminal studies of Till and McCulloch in the 1960s, the popular paradigm on adult stem cells has been that lineage-restricted stem cells are derived from pluripotent stem cells very early during development. To many, and consistent with much data, the restriction to particular lineages was considered absolute. In other words, there was a sense of determinism in the stem quality of particular stem cells: once they were allocated, they were programmed to specific roles in a given tissue. Furthermore, some adult tissues were considered devoid of detectable stem cell presence or activity.


Download Animal and Plant Stem Cells PDF

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Publisher : Springer
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ISBN 10 : 9783319477633
Pages : 234 pages
Rating : 4.3/5 (319 users)

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Download Animal and Plant Stem Cells PDF by Mirjana Pavlović Full Free and published by Springer. This book was released on 2017-02-08 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a multifaceted look into the world of stem cells and explains the similarities and differences between plant and human stem cells. It explores the intersection between animals and plants and explains their cooperative role in bioengineering studies. The book treats both theoretical and practical aspects of stem cell research. It covers the advantages and limitations of many common applications related to stem cells: their sources, categories, engineering of these cells, reprogramming of their functions, and their role as novel cellular therapeutic approach. Written by experts in the field, the book focuses on aspects of stem cells ranging from expansion-propagation to metabolic reprogramming. It introduces the emergence of cancer stem cells and different modalities in targeted cancer stem cell therapies. It is a valuable source of fresh information for academics and researchers, examining molecular mechanisms of animal and plant stem cell regulation and their usage for therapeutic applications. Students at all levels of medical or engineering backgrounds will enjoy the case studies that illustrate and explain mechanisms, interactions, targeted effects, and multimodal therapeutic approaches. Academics, researchers, and professionals who want to expand their knowledge in this field will find this book an exceptional resource.


Download Stem Cell Systems Bioengineering PDF

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Publisher : Frontiers Media SA
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ISBN 10 : 9782889668953
Pages : 214 pages
Rating : 4.8/5 (889 users)

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Download Stem Cell Systems Bioengineering PDF by Tiago G. Fernandes Full Free and published by Frontiers Media SA. This book was released on 2021-07-02 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Stephanie Willerth has a commercialization agreement with Aspect Biosystems with regards to bioprinting stem cell derived tissues. Dr. Yuguo Lei is a co-founder of CellGro Technologies, LLC, a company focusing on cell expansion technologies. Dr. Tiago Fernandes has no competing interests with regards to this Research Topic.


Download Stem Cell Therapy for Autoimmune Disease PDF

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Publisher : CRC Press
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ISBN 10 : 9781000716856
Pages : 512 pages
Rating : 4.0/5 ( users)

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Download Stem Cell Therapy for Autoimmune Disease PDF by Richard K. Burt Full Free and published by CRC Press. This book was released on 2019-11-11 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell transplantation may be complicated by treatment-related mortality and like the immune system that it regenerates has equal potential to either create and preserve or destroy. The dual nature that defines stem cells is differentiation that ultimately leads to death and self-renewal, which leads to immortality. What types of stem cells are there? How are they collected? What are their attributes and characteristics? This textbook devotes many chapters to familiarize the reader with the basic science, clinical aspects, and new questions being raised in the field of stem cell biology. Blood stem cells for tolerance and tissue regeneration are a rapidly developing research and clinical field that is being applied to autoimmune diseases. In clinical trials, autologous hematopoietic (blood) stem cells are being used to reduce the cytopenic interval following intense immune suppressive transplant regimens. While as yet not delineated, some possible mechanisms and pathways leading to tolerance after hematopoietic stem cell transplantation are suggested in these chapters. Tissue regeneration from blood stem cells is also suggested by animal experiments on stem cell plasticity or metamoirosis (i.e., change in fate) as described within this textbook. Ongoing early clinical trials on tissue regeneration from blood stem cells are described in the chapter on stem cell therapy for cardiac and peripheral vascular disease. Whether autologous hematopoietic stem cells, through the process of mobilization and reinfusion, may be manipulated to contribute to tissue repair in autoimmune diseases is a future area for translational research.


Download Philosophy of Stem Cell Biology PDF

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Publisher : Springer
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ISBN 10 : 9781137296023
Pages : 274 pages
Rating : 4.1/5 (137 users)

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Download Philosophy of Stem Cell Biology PDF by M. Fagan Full Free and published by Springer. This book was released on 2013-01-21 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This examination of stem cell biology from a philosophy of science perspective clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. Relations to systems biology and clinical medicine are also discussed.


Download Human Neural Stem Cells PDF

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Publisher : Springer
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ISBN 10 : 9783319934853
Pages : 329 pages
Rating : 4.3/5 (319 users)

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Download Human Neural Stem Cells PDF by Leonora Buzanska Full Free and published by Springer. This book was released on 2018-09-12 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action. The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.


Download Epigenetic Mechanisms in Neural Plasticity PDF

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Publisher : Frontiers Media SA
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ISBN 10 : 9782889630004
Pages : 159 pages
Rating : 4.8/5 (889 users)

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Download Epigenetic Mechanisms in Neural Plasticity PDF by Daniel Ortuño-Sahagún Full Free and published by Frontiers Media SA. This book was released on 2019-09-20 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural plasticity is a unique and adaptive feature of nervous system, which allows neurons to reorganize their interactions in response to a stimulation (intrinsic or extrinsic) to maintain their function. For these reasons, epigenetics emerges as a potential field for developing strategies to modulate changes in pathological situation because extrinsic factors and pharmacological tools can modify neural functioning in organisms during their life. Diet, exercise, environmental aspects, stressors or drugs are available to alter those mechanisms. Epigenetic involves certain molecular signaling pathways, as DNA methylation and histone acetylation and deacetylation, and the emerging non-coding small RNA, mainly microRNA, as a commanders of a number of translation processes. As most of molecular nervous cell alterations, epigenetic mechanisms play an important role in neural plasticity. This eBook collects the burgeoning advances in epigenetic mechanisms, focusing on new insights into cellular and molecular neurobiological mechanisms that underlie brain functioning in health and pathological conditions. Contributions go from basic cellular mechanism to therapeutic opportunities to tackle the challenges on nervous central system development and neurodegeneration.


Download Life Before Birth PDF

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Publisher : Oxford University Press
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ISBN 10 : 0199712077
Pages : 328 pages
Rating : 4.7/5 (712 users)

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Download Life Before Birth PDF by Bonnie Steinbock Full Free and published by Oxford University Press. This book was released on 2011-07-11 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life Before Birth provides a coherent framework for addressing bioethical issues in which the moral status of embryos and fetuses is relevant. It is based on the "interest view" which ascribes moral standing to beings with interests, and connects the possession of interests with the capacity for conscious awareness or sentience. The theoretical framework is applied to ethical and legal topics, including abortion, prenatal torts, wrongful life, the crime of feticide, substance abuse by pregnant women, compulsory cesareans, assisted reproduction, and stem cell research. Along the way, difficult philosophical problems, such as identity and the non-identity problem are thoroughly explored. The book will be of interest not only to philosophers, but also physicians, lawyers, policy makers, and anyone perplexed by the many difficulties surrounding the unborn. "Bonnie Steinbock's excellent book is . . . consistent, thoroughgoing, and intelligible." --Nature "Steinbock's book is valuable for all interested in the ethical/legal issues surrounding abortion, prenatal injury and liability, maternal-fetal conflict, and fetal/embryo research. The author provides an excellent historical overview of these issues, but she also addresses the issues from the stance of a particular theory of moral status, namely, interest theory. This gives coherence to her discussion as well as allowing testing of the viability of interest theory." --Choice "A focused, lucid, analytically fine-grained discussion of a wide variety of problems. . . extremely useful as a survey of the current state of the debate." --Religious Studies Review "Merits serious consideration by physicians. Steinbock's interests-based approach treats all questions as open -- another and most welcome breath of fresh air." -New England Journal of Medicine "An extremely valuable contribution to the literature. The author carefully identifies the many bioethical issues to which the status of embryos and fetuses is relevant....She thoroughly reviews the extensive medical, bioethical, and legal literature on all of these issues, offering well-developed critiques of many standard positions. She articulates and thoughtfully defends interesting positions on all of theses topics. Anyone with an interest in these issues will learn a great deal from her knowledgeable and judicious treatment of them." -- The Journal of Clinical Ethics


Download Stem Cells PDF

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Publisher : Springer Nature
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ISBN 10 : 9783030312060
Pages : 406 pages
Rating : 4.0/5 (3 users)

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Download Stem Cells PDF by Mariusz Z. Ratajczak Full Free and published by Springer Nature. This book was released on 2020-01-02 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since different types of stem cells for therapeutic applications have recently been proposed, this timely volume explores various sources of stem cells for tissue and organ regeneration and discusses their advantages and limitations. Also discussed are pros and cons for using embryonic stem cells, induced pluripotent stem cells, and adult stem cells isolated from postnatal tissues. Different types of adult stem cells for therapeutic applications are also reviewed, including hematopoietic stem cells, epidermal stem cells, endothelial progenitors, neural stem cells, mesenchymal stem cells, and very small embryonic-like stem cells. This book also addresses paracrine effects of stem cells in regenerative medicine that are mediated by extracellular microvesicles and soluble secretome. Finally, potential applications of stem cells in cardiology, gastroenterology, neurology, immunotherapy, and aging are presented. This is an ideal book for students and researchers working in the stem cell research field.


Download Regulating Human Embryonic Stem Cell in China PDF

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Publisher : Springer
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ISBN 10 : 9789811021015
Pages : 200 pages
Rating : 4.8/5 (811 users)

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Download Regulating Human Embryonic Stem Cell in China PDF by Li Jiang Full Free and published by Springer. This book was released on 2016-08-01 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The general scope of the book is the patentability and morality of human embryonic stem cell research in US, EU and China. The book observes fraudsters operate unsafe human embryonic stem cell therapies and officialdom turns a blind eye to the immoral human embryonic stem cell research in China. The book highlights that both patent control and federal funding control are inefficient and ineffective way to monitoring human embryonic stem cell research. The book finally proposed an approach for china to regulating human embryonic stem cell research-regulating research itself at the reconciled international regime. The potential reader includes academics and practitioners dealing with intellectual property, patent law and stem cell inventions. The topic discussed will also be interesting to a broad readership, including experts, regulators, policy makers and medical researchers in both ethical and legal disciplines in the field of embryonic stem cell research.


Download Current Medical Research and Opinion PDF

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ISBN 10 : UCLA:L0098817489
Pages : 1038 pages
Rating : 4.:/5 ( users)

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Download Current Medical Research and Opinion PDF by Full Free and published by . This book was released on 2006 with total page 1038 pages. Available in PDF, EPUB and Kindle. Book excerpt:


Download Fetal Stem Cells in Regenerative Medicine PDF

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Publisher : Springer
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ISBN 10 : 9781493934836
Pages : 453 pages
Rating : 4.4/5 (493 users)

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Download Fetal Stem Cells in Regenerative Medicine PDF by Dario O. Fauza Full Free and published by Springer. This book was released on 2016-05-02 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the regenerative properties of fetal stem cells, from feto-maternal cell traffic through perinatal stem cells, with a discussion of key topics including stem cell banking, drug screening, in utero stem cell transplantation and ethical considerations. The expertly authored chapters also delve into embryonic, amniotic membrane, and umbilical cord blood stem cells; fetal development models; fetal cell reprogramming; culture methods; disease models; perinatal gene therapy, and more. These chapters are grouped into four sections, each discussing a separate prenatal stem cell population and providing fascinating historical contexts for our knowledge of these systems. Featuring a foreword written by the renowned Dr. Joseph Vacanti of the Harvard Stem Cell Institute, Fetal Stem Cells in Regenerative Medicine: Principles and Translational Strategies is a welcome and timely contribution to the Stem Cell Biology and Regenerative Medicine series. It is essential reading for scientists and researchers, clinicians and residents, and advanced students involved in stem cells, regenerative medicine, tissue engineering, and related disciplines such as embryology.


Download Encyclopedia of Stem Cell Research PDF

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Publisher : SAGE
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ISBN 10 : 9781412959087
Pages : 953 pages
Rating : 4.4/5 (412 users)

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Download Encyclopedia of Stem Cell Research PDF by Full Free and published by SAGE. This book was released on 2008 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Provides an understanding of the basic concepts in stem cell biology and addresses the politics, ethics, and challenges currently facing the field"--From publisher description.


Download Regenerative Medicine and Stem Cell Therapy for the Eye PDF

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Publisher : Springer
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ISBN 10 : 9783319980805
Pages : 212 pages
Rating : 4.3/5 (319 users)

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Download Regenerative Medicine and Stem Cell Therapy for the Eye PDF by Brian G. Ballios Full Free and published by Springer. This book was released on 2019-02-18 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the types, sources, and applications of stem cells in regenerating various ocular tissues, with a perspective on both potential applications of stem cells and possible challenges. The scope of the chapters include both preclinical and clinical applications, including stem cell-derived therapies based on endogenous tissue repair; stem cell transplantation and cell replacement therapy; gene therapy; and in vitro disease modelling. Additionally, the volume presents applications in both anterior and posterior ocular disease, with a particular focus on diseases of the ocular surface, cornea, limbus, and retina, including inherited retinal dystrophies as well as acquired diseases, such as age-related macular degeneration. Regenerative Medicine and Stem Cell Therapy for the Eye is an ideal book for advanced researchers in stem cell and ocular biology as well as clinical ophthalmologists, and will be of interest to readers with backgrounds in developmental biology and bioengineering. This book also Skillfully reviews cutting-edge advances in stem cell biology as applied to regenerative medicine and ocular disease Provides expert viewpoints on key hurdles and challenges to successful implementation of stem cell-derived therapies in the clinical domain Offers a multi-disciplinary, broad understanding of cell-based therapies for ocular diseases by incorporating perspectives from biomedical scientists, physicians, and engineers Examines the connection between cell therapy and gene editing, in particular relation to ocular disease


Download How Adult Stem Cell Therapies Saved My Life PDF

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Publisher : AuthorHouse
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ISBN 10 : 9781600080371
Pages : 175 pages
Rating : 4.6/5 (6 users)

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Download How Adult Stem Cell Therapies Saved My Life PDF by Bernard Van Zyl Full Free and published by AuthorHouse. This book was released on 2007 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2000, after receiving bypass surgery, an angioplasty, and entering a cardiac rehabilitation program, van Zyls heart was deteriorating. Turned down by two heart transplant centers, van Zyls only hope was in a new FDA-approved clinical trial for adult stem cell therapies. In this work, van Zyl offers information on the latest adult stem cell treatments for more than a dozen diseases and conditions.